Gooptu, Bibekbrata and Lomas, D.A. (2008) Polymers and inflammation: disease mechanisms of the serpinopathies. The Journal of Experimental Medicine 205 (7), pp. 1529-1534. ISSN 0022-1007.
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Members of the serpin (serine proteinase inhibitor) superfamily play a central role in the control of inflammatory, coagulation, and fibrinolytic cascades. Point mutations that cause abnormal conformational transitions in these proteins can trigger disease. Recent work has defined three pathways by which these conformers cause tissue damage. Here, we describe how these three mechanisms can be integrated into a new model of the pathogenesis of emphysema caused by mutations in the serpin α1-antitrypsin.
|School or Research Centre:||Birkbeck Schools and Research Centres > School of Science > Biological Sciences|
|Depositing User:||Sarah Hall|
|Date Deposited:||14 Jun 2012 10:11|
|Last Modified:||17 Apr 2013 12:33|
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