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    Polymers and inflammation: disease mechanisms of the serpinopathies

    Gooptu, Bibek and Lomas, D.A. (2008) Polymers and inflammation: disease mechanisms of the serpinopathies. The Journal of Experimental Medicine 205 (7), pp. 1529-1534. ISSN 0022-1007.

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    Abstract

    Members of the serpin (serine proteinase inhibitor) superfamily play a central role in the control of inflammatory, coagulation, and fibrinolytic cascades. Point mutations that cause abnormal conformational transitions in these proteins can trigger disease. Recent work has defined three pathways by which these conformers cause tissue damage. Here, we describe how these three mechanisms can be integrated into a new model of the pathogenesis of emphysema caused by mutations in the serpin α1-antitrypsin.

    Metadata

    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Research Centre: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Sarah Hall
    Date Deposited: 14 Jun 2012 10:11
    Last Modified: 06 Dec 2016 10:42
    URI: http://eprints.bbk.ac.uk/id/eprint/4775

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