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Go hybrid: EM, crystallography, and beyond

Lander, G.C. and Saibil, Helen R. and Nogales, E. (2012) Go hybrid: EM, crystallography, and beyond. Current Opinion in Structural Biology 22 (5), pp. 627-635. ISSN 0959-440X.

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A mechanistic understanding of the molecular transactions that govern cellular function requires knowledge of the dynamic organization of the macromolecular machines involved in these processes. Structural biologists employ a variety of biophysical methods to study large macromolecular complexes, but no single technique is likely to provide a complete description of the structure–function relationship of all the constituent components. Since structural studies generally only provide snapshots of these dynamic machines as they accomplish their molecular functions, combining data from many methodologies is crucial to our understanding of molecular function.

Item Type: Article
School or Research Centre: Birkbeck Schools and Research Centres > School of Science > Biological Sciences
Depositing User: Administrator
Date Deposited: 13 Sep 2012 09:48
Last Modified: 17 Apr 2013 12:24

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