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Fibronectin: a multidomain host adhesin targeted by bacterial fibronectin-binding proteins

Henderson, B. and Nair, S.P. and Pallas, J. and Williams, Mark A. (2011) Fibronectin: a multidomain host adhesin targeted by bacterial fibronectin-binding proteins. FEMS Microbiology Reviews 35 (1), pp. 147-200. ISSN 1574-6976.

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Official URL: http://dx.doi.org/10.1111/j.1574-6976.2010.00243.x

Abstract

Fibronectin, a large and essential multidomain glycoprotein, with multiple adhesive properties, functioning as a key link between cells and their extracellular matrices, is now recognized to be the target for a large number of bacterial proteins, which are generally considered to function as bacterial adhesins. In the last decade, an avalanche of bacterial fibronectin-binding proteins (FnBPs) has been identified, and the bioinformatics, structural biology, biological function and role in the virulence of a growing number of both Gram-positive and Gram-negative proteins have begun to emerge. The evidence suggests that fibronectin has a wider biological remit than was previously thought and that bacterial FnBPs have actions over and above that of simple adhesion. This article provides an update on our current understanding of FnBPs from both Gram-negative and Gram-positive bacteria and their proposed roles in bacterial colonization, bacterial virulence and bacteria–host interactions.

Item Type: Article
School or Research Centre: Birkbeck Schools and Research Centres > School of Science > Biological Sciences
Depositing User: Dr Mark A. Williams
Date Deposited: 15 Nov 2012 13:41
Last Modified: 17 Apr 2013 12:26
URI: http://eprints.bbk.ac.uk/id/eprint/5661

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