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    Mapping the human cortical surface by combining quantitative T1 with Retinotopy

    Sereno, Martin I. and Lutti, A. and Weiskopf, N. and Dick, Frederic (2013) Mapping the human cortical surface by combining quantitative T1 with Retinotopy. Cerebral Cortex 23 (9), pp. 2261-2268. ISSN 1047-3211.

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    Abstract

    We combined quantitative relaxation rate (R1= 1/T1) mapping—to measure local myelination—with fMRI-based retinotopy. Gray–white and pial surfaces were reconstructed and used to sample R1 at different cortical depths. Like myelination, R1 decreased from deeper to superficial layers. R1 decreased passing from V1 and MT, to immediately surrounding areas, then to the angular gyrus. High R1 was correlated across the cortex with convex local curvature so the data was first “de-curved”. By overlaying R1 and retinotopic maps, we found that many visual area borders were associated with significant R1 increases including V1, V3A, MT, V6, V6A, V8/VO1, FST, and VIP. Surprisingly, retinotopic MT occupied only the posterior portion of an oval-shaped lateral occipital R1 maximum. R1 maps were reproducible within individuals and comparable between subjects without intensity normalization, enabling multi-center studies of development, aging, and disease progression, and structure/function mapping in other modalities.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): MT, myelination, parcellation, surface reconstruction, visual areas
    School: Birkbeck Schools and Departments > School of Science > Psychological Sciences
    Research Centre: Brain and Cognitive Development, Centre for (CBCD)
    Depositing User: Administrator
    Date Deposited: 01 May 2013 08:02
    Last Modified: 02 Dec 2016 11:18
    URI: http://eprints.bbk.ac.uk/id/eprint/6544

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