Dynamic causal modelling of effective connectivity during perspective taking in a communicative task
Hillebrandt, H. and Dumontheil, Iroise and Blakemore, S.J. and Roiser, J.P. (2013) Dynamic causal modelling of effective connectivity during perspective taking in a communicative task. NeuroImage 76 , pp. 116-124. ISSN 1053-8119.
Previous studies have shown that taking into account another person's perspective to guide decisions is more difficult when their perspective is incongruent from one's own compared to when it is congruent. Here we used dynamic causal modelling (DCM) for functional magnetic resonance imaging (fMRI) to investigate effective connectivity between prefrontal and posterior brain regions in a task that requires participants to take into account another person's perspective in order to guide the selection of an action. Using a new procedure to score model evidence without computationally costly estimation, we conducted an exhaustive search for the best of all possible models. The results elucidate how the activity in the areas from our previously reported analysis (Dumontheil et al., 2010) are causally linked and how the connections are modulated by both the social as well as executive task demands of the task. We find that the social demands modulate the backward connections from the medial prefrontal cortex (MPFC) more strongly than the forward connections from the superior occipital gyrus (SOG) and the medial temporal gyrus (MTG) to the MPFC. This was also the case for the backward connection from the MTG to the SOG. Conversely, the executive task demands modulated the forward connections of the SOG and the MTG to the MPFC more strongly than the backward connections. We interpret the results in terms of hierarchical predictive coding.
|Additional Information:||NOTICE: this is the author’s version of a work that was accepted for publication in Neuroimage. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neuroimage 76 August 2013, DOI: http://dx.doi.org/10.1016/j.neuroimage.2013.02.072|
|Keyword(s) / Subject(s):||Dynamic causal modelling, Effective connectivity, Theory of mind, Perspective taking, Social brain, Exhaustive modelling, Hierarchical predictive coding|
|School:||Birkbeck Schools and Departments > School of Science > Psychological Sciences|
|Research Centre:||Educational Neuroscience, Centre for, Brain and Cognitive Development, Centre for (CBCD)|
|Date Deposited:||01 May 2013 10:06|
|Last Modified:||09 Dec 2016 11:17|
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