Genome-wide association study of receptive language ability of 12 year olds
Harlaar, N. and Meaburn, Emma L. and Hayiou-Thomas, M.E. and Davis, O.S.P. and Docherty, S.J. and Hanscombe, K.B. and Haworth, C. and Price, T.S and Trzaskowski, M. and Dale, P. and Plomin, R. (2013) Genome-wide association study of receptive language ability of 12 year olds. Journal of Speech, Language, and Hearing Research , ISSN 1092-4388.
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Purpose: We have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. The current study attempted to identify some of the genes responsible for the heritability of receptive language ability using a genome-wide association (GWA) approach. Method: We administered four internet-based measures of receptive language (vocabulary, semantics, syntax, and pragmatics) to a sample of 2329 12-year-olds for whom DNA and genome-wide genotyping were available. Nearly 700,000 single-nucleotide polymorphisms (SNPs) and one million imputed SNPs were included in a GWA analysis of receptive language composite scores. Results: No SNP associations met the demanding criterion of genome-wide significance that corrects for multiple testing across the genome (p < 5 ×10-8). The strongest SNP association did not replicate in an additional sample of 2639 12-year-olds. Conclusion: These results indicate that individual differences in receptive language ability in the general population do not reflect common genetic variants that account for >3% of the phenotypic variance. The search for genetic variants associated with language skill will require larger samples and additional methods to identify and functionally characterize the full spectrum of risk variants.
|Additional Information:||Co-authored by Wellcome Trust Case Control Consortium|
|Keyword(s) / Subject(s):||receptive language, adolescents, genome-wide association study, genetics|
|School:||Birkbeck Schools and Departments > School of Science > Psychological Sciences|
|Research Centre:||Educational Neuroscience, Centre for, Brain and Cognitive Development, Centre for (CBCD)|
|Depositing User:||Emma Meaburn|
|Date Deposited:||09 Jan 2014 10:59|
|Last Modified:||09 Dec 2016 11:16|
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