Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits
Wong, C.C.Y. and Meaburn, Emma L. and Ronald, Angelica and Price, T.S and Jeffries, A.R. and Schalkwyk, L.C. and Plomin, R. and Mill, J. (2014) Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Molecular Psychiatry 19 (4), pp. 495-503. ISSN 1359-4184.
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Autism spectrum disorder (ASD) defines a group of common, complex neurodevelopmental disorders. Although the aetiology of ASD has a strong genetic component, there is considerable monozygotic (MZ) twin discordance indicating a role for non-genetic factors. Because MZ twins share an identical DNA sequence, disease-discordant MZ twin pairs provide an ideal model for examining the contribution of environmentally driven epigenetic factors in disease. We performed a genome-wide analysis of DNA methylation in a sample of 50 MZ twin pairs (100 individuals) sampled from a representative population cohort that included twins discordant and concordant for ASD, ASD-associated traits and no autistic phenotype. Within-twin and between-group analyses identified numerous differentially methylated regions associated with ASD. In addition, we report significant correlations between DNA methylation and quantitatively measured autistic trait scores across our sample cohort. This study represents the first systematic epigenomic analyses of MZ twins discordant for ASD and implicates a role for altered DNA methylation in autism.
|Keyword(s) / Subject(s):||ASD, autism, copy-number variation, DNA methylation, epigenetics, monozygotic twins|
|School:||Birkbeck Schools and Departments > School of Science > Psychological Sciences|
|Research Centre:||Educational Neuroscience, Centre for, Brain and Cognitive Development, Centre for (CBCD)|
|Depositing User:||Emma Meaburn|
|Date Deposited:||15 May 2013 09:41|
|Last Modified:||09 Dec 2016 11:16|
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