Childhood intelligence is heritable, highly polygenic and associated with FNBP1L
Benyamin, B. and St. Pourcain, B. and Davis, O.S.P. and Davies, G. and Hansell, N.K. and Brion, M.-Ja and Kirkpatrick, R.M. and Cents, R.A.M. and Franić, S. and Miller, M.B. and Haworth, C. and Meaburn, Emma L. and Price, T.S and Evans, D.M. and Timpson, N. and Kemp, J. and Ring, S. and McArdle, W. and Medland, S.E. and Yang, J. and Harris, S.E. and Liewald, D.C. and Scheet, P. and Xiao, X. and Hudziak, J.J. and de Geus, E.J.C. and Jaddoe, V.W.V. and Starr, J.M. and Verhulst, F.C. and Pennell, C.E. and Tiemeier, H. and Iacono, W.G. and Palmer, L.J. and Montgomery, G.W. and Martin, N.G. and Boomsma, D.I. and Posthuma, D. and McGue, M. and Wright, M.J. and Davey Smith, G. and Deary, I.J. and Plomin, R. and Visscher, P.M. (2014) Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Molecular Psychiatry 19 , pp. 253-258. ISSN 1359-4184.
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Intelligence in childhood, as measured by psychometric cognitive tests, is a strong predictor of many important life outcomes, including educational attainment, income, health and lifespan. Results from twin, family and adoption studies are consistent with general intelligence being highly heritable and genetically stable throughout the life course. No robustly associated genetic loci or variants for childhood intelligence have been reported. Here, we report the first genome-wide association study (GWAS) on childhood intelligence (age range 6-18 years) from 17 989 individuals in six discovery and three replication samples. Although no individual single-nucleotide polymorphisms (SNPs) were detected with genome-wide significance, we show that the aggregate effects of common SNPs explain 22-46% of phenotypic variation in childhood intelligence in the three largest cohorts (P=3.9 × 10(-15), 0.014 and 0.028). FNBP1L, previously reported to be the most significantly associated gene for adult intelligence, was also significantly associated with childhood intelligence (P=0.003). Polygenic prediction analyses resulted in a significant correlation between predictor and outcome in all replication cohorts. The proportion of childhood intelligence explained by the predictor reached 1.2% (P=6 × 10(-5)), 3.5% (P=10(-3)) and 0.5% (P=6 × 10(-5)) in three independent validation cohorts. Given the sample sizes, these genetic prediction results are consistent with expectations if the genetic architecture of childhood intelligence is like that of body mass index or height. Our study provides molecular support for the heritability and polygenic nature of childhood intelligence. Larger sample sizes will be required to detect individual variants with genome-wide significance.Molecular Psychiatry advance online publication, 29 January 2013; doi:10.1038/mp.2012.184.
|Keyword(s) / Subject(s):||intelligence, IQ, cognitive, association, FNBP1L, polygenic|
|School:||Birkbeck Schools and Departments > School of Science > Psychological Sciences|
|Research Centre:||Educational Neuroscience, Centre for, Brain and Cognitive Development, Centre for (CBCD)|
|Depositing User:||Emma Meaburn|
|Date Deposited:||15 May 2013 10:10|
|Last Modified:||09 Dec 2016 11:16|
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