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    Deciphering interplay between Salmonella invasion effectors

    Isberg, R.R. and Hayward, Richard D. and Cain, R.J. and Koronakis, V. (2008) Deciphering interplay between Salmonella invasion effectors. PLoS Pathogens 4 (4), e1000037. ISSN 1553-7374.

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    Abstract

    Bacterial pathogens have evolved a specialized type III secretion system (T3SS) to translocate virulence effector proteins directly into eukaryotic target cells. Salmonellae deploy effectors that trigger localized actin reorganization to force their own entry into non-phagocytic host cells. Six effectors (SipC, SipA, SopE/2, SopB, SptP) can individually manipulate actin dynamics at the plasma membrane, which acts as a ‘signaling hub’ during Salmonella invasion. The extent of crosstalk between these spatially coincident effectors remains unknown. Here we describe trans and cis binary entry effector interplay (BENEFIT) screens that systematically examine functional associations between effectors following their delivery into the host cell. The results reveal extensive ordered synergistic and antagonistic relationships and their relative potency, and illuminate an unexpectedly sophisticated signaling network evolved through longstanding pathogen–host interaction.

    Metadata

    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Research Centre: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 16 May 2013 09:44
    Last Modified: 09 May 2018 18:08
    URI: http://eprints.bbk.ac.uk/id/eprint/6788

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