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    Predictive 3D modelling of the interactions of pyrethroids with the voltage-gated sodium channels of ticks and mites

    O'Reilly, A.O. and Williamson, M.S. and González-Cabrera, J. and Turberg, A. and Field, L.M. and Wallace, Bonnie A. and Emyr Davies, T.G. (2014) Predictive 3D modelling of the interactions of pyrethroids with the voltage-gated sodium channels of ticks and mites. Pest Management Science 70 (3), pp. 369-377. ISSN 1526-498X.

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    Abstract

    Background: The pyrethroid insecticides are a very successful group of compounds that target invertebrate voltage-gated sodium channels and are widely used in the control of insects, ticks and mites. It is well established that some pyrethroids are good insecticides whereas others are more effective as acaricides. This species specificity is advantageous for controlling particular pest(s) in the presence of another non-target invertebrate, for example controlling the Varroa mite in honey bee colonies. Results: We applied in-silico techniques to compare the voltage-gated sodium channels of insects versus ticks and mites and their interactions with a range of pyrethroids and DDT analogues. We identified a single amino acid difference within the pyrethroid binding pocket of ticks/mites that may have significant impact on the effectiveness of pyrethroids as acaricides. Other individual amino acid differences within the binding pocket in distinct tick and mite species may provide a basis for future acaricidal selectivity. Conclusions: 3D modelling of the pyrethroid/DDT receptor site has led to a new hypothesis to explain the preferential binding of acaricidal pyrethroids to the sodium channels of ticks/mites. This is important for understanding pyrethroid selectivity and the potential effects of mutations that can give rise to resistance to pyrethroids in commercially-important pest species.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Voltage-gated sodium channel, pyrethroids, DDT, acaricides, resistance, ticks, mites
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Research Centre: Bioinformatics, Bloomsbury Centre for, Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 06 Jun 2013 15:17
    Last Modified: 07 Dec 2016 15:05
    URI: http://eprints.bbk.ac.uk/id/eprint/7325

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