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    Why do only some institutionalized children become indiscriminately friendly? Insights from the study of Williams Syndrome

    Soares, I. and Belsky, Jay and Mesquita, A.R. and Osório, A. and Sampaio, A. (2013) Why do only some institutionalized children become indiscriminately friendly? Insights from the study of Williams Syndrome. Child Development Perspectives 7 (3), pp. 187-192. ISSN 1750-8592.

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    Abstract

    Why do some institutionalized children develop indiscriminate behavior (IB) while others do not? Considering children with Williams syndrome (WS) may provide an answer because IB has been observed routinely among individuals with this rare genetic neurodevelopmental disorder. By conceiving WS as a natural genetic model that mimics the indiscriminate phenotype and, more importantly, is associated with the deletion of genes in a specific region, we propose an integrative conceptual framework that underscores the dynamic developmental interplay between genes, endophenotypes, and environment. In this article, we consider the etiology of IB among institutionalized children, which emphasizes environmental factors, followed by the effect of such behavior on WS children's hypersociability, which highlights the crosstalk between genes and neuropsychological features in programming their distinctive social-emotional and behavioral phenotype. We propose new hypotheses regarding the etiopathogeny of IBs in institutionalized children, particularly the prediction of specific Gene × Environment interactions.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): indiscriminate behavior, institutionalized children, Williams syndrome
    School: Birkbeck Schools and Departments > School of Science > Psychological Sciences
    Depositing User: Administrator
    Date Deposited: 21 Jun 2013 07:55
    Last Modified: 14 Feb 2014 11:09
    URI: http://eprints.bbk.ac.uk/id/eprint/7546

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