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    MAPping out distribution routes for kinesin couriers

    Atherton, Joseph and Houdusse, A. and Moores, Carolyn A. (2013) MAPping out distribution routes for kinesin couriers. Biology of the Cell 105 (10), pp. 465-487. ISSN 0248-4900.

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    Abstract

    In the crowded environment of eukaryotic cells, diffusion is an inefficient distribution mechanism for cellular components. Long-distance active transport is required and is performed by molecular motors including kinesins. Furthermore, in highly polarized, compartmentalized and plastic cells such as neurons, regulatory mechanisms are required to ensure appropriate spatio-temporal delivery of neuronal components. The kinesin machinery has diversified into a large number of kinesin motor proteins as well as adaptor proteins that are associated with subsets of cargo. However, many mechanisms contribute to the correct delivery of these cargos to their target domains. One mechanism is through motor recognition of subdomain-specific microtubule (MT) tracks, sign-posted by different tubulin isoforms, tubulin post-translational modifications (PTMs), tubulin GTPase activity and MT associated proteins (MAPs). With neurons as a model system, a critical review of these regulatory mechanisms is presented here, with particular focus on the emerging contribution of compartmentalised MAPs. Overall, we conclude that – especially for axonal cargo – alterations to the MT track can influence transport, although in vivo, it is likely that multiple track-based effects act synergistically to ensure accurate cargo distribution.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): kinesin, MAP, microtubule, neuron, transport
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Research Centre: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 26 Jun 2013 12:29
    Last Modified: 06 Dec 2016 11:12
    URI: http://eprints.bbk.ac.uk/id/eprint/7569

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