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    Structures of mitochondrial oxidative phosphorylation supercomplexes and mechanisms for their stabilisation

    Chaban, Y. and Boekema, E.J. and Dudkina, Natalia (2014) Structures of mitochondrial oxidative phosphorylation supercomplexes and mechanisms for their stabilisation. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1837 (4), pp. 418-426. ISSN 0005-2728.

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    Abstract

    Oxidative phosphorylation (OXPHOS) is the main source of energy in eukaryotic cells. This process is performed by means of electron flow between four enzymes, of which three are proton pumps, in the inner mitochondrial membrane. The energy accumulated in the proton gradient over the inner membrane is utilized for ATP synthesis by a fifth OXPHOS complex, ATP synthase. Four of the OXPHOS protein complexes associate into stable entities called respiratory supercomplexes. This review summarises the current view on the arrangement of the electron transport chain in mitochondrial cristae. The functional role of the supramolecular organisation of the OXPHOS system and the factors that stabilise such organisation are highlighted. This article is part of a Special Issue entitled: Dynamic and ultrastructure of bioenergetic membranes and their components.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): ATP synthase, Electron microscopy, Mitochondria, Oxidative phosphorylation, Supercomplex
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Depositing User: Administrator
    Date Deposited: 22 Nov 2013 08:58
    Last Modified: 14 Feb 2014 12:20
    URI: http://eprints.bbk.ac.uk/id/eprint/8757

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