The evolution of specificity in large protein families
Thornton, Janet M. and Favia, A.D. and Nobeli, Irilenia and Furnham, N. (2008) The evolution of specificity in large protein families. In: 33rd FEBS Congress & 11th IUBMB Conference: Biochemistry of Cell Regulation, June 28-July 3 2008, Athens, Greece.
Understanding the relationship between protein structure and biological function has long been a major goal of structural biology. With the advent of many structural genomics projects, there is a practical need for tools to analyse and characterise the possible functional attributes for a new structure. One of the major challenges in assigning function is to recognise a cognate ligand which may be a small molecule or a large macromolecule. At EBI we have been developing a range of methods which seek to annotate a functional site. These methods have some success dependent upon the shape and flexibility of the binding site. In this presentation I will review our progress in this area and describe application to two large families – the sulpher transferases (1) and the short chain ehydrogenase/reductases (2).
|Item Type:||Conference or Workshop Item (Lecture)|
|Additional Information:||Lecture abstract only|
|School:||Birkbeck Schools and Departments > School of Science > Biological Sciences|
|Research Centre:||Bioinformatics, Bloomsbury Centre for, Structural Molecular Biology, Institute of (ISMB)|
|Date Deposited:||04 Aug 2010 14:09|
|Last Modified:||07 Dec 2016 15:00|
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