BIROn - Birkbeck Institutional Research Online

    RpfC (Rv1884) atomic structure shows high structural conservation within the resuscitation promoting factor catalytic domain

    Chauviac, Francois-Xavier and Robertson, Giles and Quay, Doris H.X. and Bagneris, Claire and Dumas, C. and Henderson, B. and Ward, J. and Keep, Nicholas H. and Cohen-Gonsaud, Martin (2014) RpfC (Rv1884) atomic structure shows high structural conservation within the resuscitation promoting factor catalytic domain. Acta Crystallographica Section F: Structural Biology Communications F70 (8), pp. 1022-1026. ISSN 1744-3091.

    [img] Text
    9949.pdf - Author's Accepted Manuscript
    Restricted to Repository staff only

    Download (6MB)
    [img]
    Preview
    Text
    9949.pdf - Published Version of Record
    Available under License Creative Commons Attribution.

    Download (816kB) | Preview

    Abstract

    We report the first structure of the catalytic domain of RpfC (Rv1884), one of theresuscitation-promoting factors (RPFs) from Mycobacterium tuberculosis. The structure was solved using molecular replacement, once the space group had been correctly identified as twinned P21 rather than the apparent C2221 by searching for anomalous scattering sites in P1. The structure displays a very high degree of structural conservation with the structures of the catalytic domains of RpfB (Rv1009) and RpfE (Rv2450) already published. This structural conservation highlights the importance of the versatile domain composition of the RPF family.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Resuscitation Promoting Factor, Peptidoglycan, X-ray Crystallography
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Research Centre: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 16 Jun 2014 11:21
    Last Modified: 06 Dec 2016 10:42
    URI: http://eprints.bbk.ac.uk/id/eprint/9949

    Statistics

    Downloads
    Activity Overview
    432Downloads
    172Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item