Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct

Barrett, T.E. and Savva, Renos and Barlow, T. and Brown, T. and Jiricny, J. and Pearl, L.H. (1998) Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct. Nature Structural Biology 5 (8), pp. 697-701. ISSN 1072-8368.

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Official URL: https://doi.org/10.1038/1394

Abstract

Base-excision of a self-complementary oligonucleotide with central G:T mismatches by the G:T/U-specific mismatch DNA glycosylase (MUG), generates an unusual DNA structure which is remarkably similar in conformation to an interstrand DNA adduct of the anti-tumor drug cis -diamminedichloroplatinum. The abasic sugars generated by excision of the mismatched thymines are extruded from the double-helix, and the 'widowed' deoxyguanosines rotate so that their N7 and O6 groups protrude into the minor groove of the duplex and restack in an interleaved intercalative geometry, generating a kink in the helix axis.

Metadata

Item Type:	Article
School:	Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
Research Centres and Institutes:	Innovation Management Research, Birkbeck Centre for
Depositing User:	Sarah Hall
Date Deposited:	14 May 2019 11:27
Last Modified:	02 Aug 2023 17:51
URI:	https://eprints.bbk.ac.uk/id/eprint/27524

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