Effects of norepinephrine infused in the paraventricular hypothalamus on energy expenditure in the rat

Siviy, S. and Kritikos, A. and Atrens, D.M. and Shepherd, Alex J. (1989) Effects of norepinephrine infused in the paraventricular hypothalamus on energy expenditure in the rat. Brain Research 487 (1), pp. 79-88. ISSN 0006-8993.

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Official URL: https://doi.org/10.1016/0006-8993(89)90942-6

Abstract

The metabolic effects of norepinephrine (NE), when infused into the paraventricular nucleus of the hypothalamus (PVN), were examined using indirect calorimetry. In two separate experiments, it was found that NE infused into the PVN reduced energy expenditure in freely moving rats. While NE also reduced motor activity, these reductions were not statistically significant. Reductions in voluntary motor activity were not necessary for a reduction in energy expenditure, as NE still reduced energy expenditure in rats that were lightly sedated. Clonidine, but notl-phenylephrine, mimicked the hypometabolic effect of NE, suggesting an action atα2 receptors. Infusions of NE were also found to increase blood glucose shortly after infusion, although the specificity of this effect is questionable. Taken together, these data suggest that activation of noradrenergic neurons within the PVN results in a metabolic shift towards energy conservation.

Metadata

Item Type:	Article
School:	Birkbeck Faculties and Schools > Faculty of Science > School of Psychological Sciences
Depositing User:	Sarah Hall
Date Deposited:	18 Feb 2020 10:54
Last Modified:	02 Aug 2023 17:57
URI:	https://eprints.bbk.ac.uk/id/eprint/30995

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