BIROn - Birkbeck Institutional Research Online

    A genome-wide association study of social and non-social autistic-like traits in the general population using pooled DNA, 500 K SNP microarrays and both community and diagnosed autism replication samples

    Ronald, Angelica and Butcher, L.M. and Docherty, S.J. and Davis, O.S.P. and Schalkwyk, L.C. and Craig, I.W. and Plomin, R. (2010) A genome-wide association study of social and non-social autistic-like traits in the general population using pooled DNA, 500 K SNP microarrays and both community and diagnosed autism replication samples. Behavior Genetics 40 (1), pp. 31-45. ISSN 0001-8244.

    Full text not available from this repository.

    Abstract

    Two separate genome-wide association studies were conducted to identify single nucleotide polymorphisms (SNPs) associated with social and nonsocial autistic-like traits. We predicted that we would find SNPs associated with social and non-social autistic-like traits and that different SNPs would be associated with social and nonsocial. In Stage 1, each study screened for allele frequency differences in ~430,000 autosomal SNPs using pooled DNA on microarrays in high-scoring versus low-scoring boys from a general population sample (N = ~400/group). In Stage 2, 22 and 20 SNPs in the social and non-social studies, respectively, were tested for QTL association by individually genotyping an independent community sample of 1,400 boys. One SNP (rs11894053) was nominally associated (P < .05, uncorrected for multiple testing) with social autistic-like traits. When the sample was increased by adding females, 2 additional SNPs were nominally significant (P < .05). These 3 SNPs, however, showed no significant association in transmission disequilibrium analyses of diagnosed ASD families.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): autistic traits, genome-wide association, autism, microarrays, heritability, pooling
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Psychological Sciences
    Research Centres and Institutes: Brain and Cognitive Development, Centre for (CBCD)
    Depositing User: Sarah Hall
    Date Deposited: 22 Jun 2012 07:10
    Last Modified: 02 Aug 2023 16:57
    URI: https://eprints.bbk.ac.uk/id/eprint/4769

    Statistics

    Activity Overview
    6 month trend
    0Downloads
    6 month trend
    484Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item