BIROn - Birkbeck Institutional Research Online
    Up a level
    Export as [feed] Atom [feed] RSS
    Number of items: 42.

    Article

    von Loeffelholz, O. and Peña, A. and Drummond, D.R. and Cross, R. and Moores, Carolyn A. (2019) Cryo-EM structure (4.5-Å) of Yeast Kinesin-5–Microtubule Complex reveals a distinct binding footprint and mechanism of drug resistance. Journal of Molecular Biology 431 (4), pp. 864-872. ISSN 0022-2836.

    Manka, Szymon and Moores, Carolyn A. (2018) Microtubule structure by cryo-EM: snapshots of dynamic instability. Essays in Biochemistry 62 (6), pp. 737-751. ISSN 1744-1358.

    Moores, Carolyn A. and Manka, S.W. (2018) The role of tubulin-tubulin lattice contacts in the mechanism of microtubule dynamic instability. Nature Structural & Molecular Biology , ISSN 1545-9993. (In Press)

    Atherton, J. and Stouffer, M. and Francis, F. and Moores, Carolyn A. (2018) Microtubule architecture in vitro and in cells revealed by cryo-electron tomography. Acta Crystallographica Section D: Structural Biology D74 , pp. 572-584. ISSN 2059-7983.

    von Loeffelholz, Ottie and Venables, N.A. and Drummond, D.R. and Katsuki, M. and Cross, R. and Moores, Carolyn A. (2017) Nucleotide– and Mal3-dependent changes in fission yeast microtubules suggest a structural plasticity view of dynamics. Nature Communications 8 (1), ISSN 2041-1723.

    Vemu, A. and Atherton, J. and Spector, J.O. and Moores, Carolyn A. and Roll-Mecak, A. and Blanchoin, L. (2017) Tubulin isoform composition tunes microtubule dynamics. Molecular Biology of the Cell 28 (25), pp. 3564-3572. ISSN 1059-1524.

    Locke, Julia and Joseph, Agnel Praveen and Pena, Alejandro and Mockel, M. and Mayer, T. and Topf, Maya and Moores, Carolyn A. (2017) Structural basis of human kinesin-8 function and inhibition. Proceedings of the National Academy of Sciences of the United States of America 114 (45), E9539-E9548. ISSN 0027-8424.

    Atherton, Joseph and Yu, I-M. and Cook, Alexander and Muretta, J. and Joseph, Agnel Praveen and Major, J. and Sourigues, Y. and Clause, J. and Topf, Maya and Rosenfeld, S. and Houdusse, A. and Moores, Carolyn A. (2017) The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry. eLife , ISSN 2050-084X.

    Atherton, Joe and Jiang, K. and Stangier, M.M. and Luo, Y. and Hua, S. and Houben, K. and von Hooff, J.J.E. and Joseph, Agnel Praveen and Scarabelli, G. and Grant, B.J. and Roberts, Anthony and Topf, Maya and Steinmetz, M. and Baldus, M. and Moores, Carolyn A. and Akhmanova, A. (2017) A structural model for microtubule minus-end recognition and protection by CAMSAP proteins. Nature Structural and Molecular Biology 24 , pp. 931-943. ISSN 1545-9993.

    Britto, M. and Goulet, A. and Rizvi, S. and von Loeffelholz, O. and Moores, Carolyn A. and Cross, R.A. (2016) Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism. Proceedings of the National Academy of Sciences of the United States of America 113 (47), E7483-E7489. ISSN 0027-8424.

    Vemu, A. and Atherton, Joe and Spector, J.O. and Szyk, A. and Moores, Carolyn A. and Roll-Mecak, A. (2016) Structure and dynamics of single-isoform recombinant Neuronal Human Tubulin. Journal of Biological Chemistry 291 (25), pp. 12907-12915. ISSN 0021-9258.

    Scarabelli, G. and Soppina, V. and Yao, X. and Atherton, J. and Moores, Carolyn A. and Verhey, K.J. and Grant, B.J. (2015) Mapping the processivity determinants of the kinesin-3 motor domain. Biophysical Journal 109 (8), pp. 1537-1540. ISSN 0006-3495.

    Bullen, A. and West, T. and Moores, Carolyn A. and Ashmore, J. and Fleck, R.A. and MacLellan-Gibson, K. and Forge, A. (2015) Association of intracellular and synaptic organization in cochlear inner hair cells revealed by 3D electron microscopy. Journal of Cell Science 128 , pp. 2529-2540. ISSN 0021-9533.

    Atherton, Joseph and Farabella, Irene and Yu, I-M. and Rosenfeld, S.S. and Houdusse, A. and Topf, Maya and Moores, Carolyn A. (2014) Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins. eLife 3 , ISSN 2050-084X.

    Bullen, A. and Taylor, R.R. and Kachar, B. and Moores, Carolyn A. and Fleck, R.A. and Forge, A. (2014) Inner ear tissue preservation by rapid freezing: improving fixation by high-pressure freezing and hybrid methods. Hearing Research 315 , pp. 49-60. ISSN 0378-5955.

    Goulet, Adeline and Major, J. and Jung, Y. and Grossmann, S.P. and Rosenfeld, S.S. and Moores, Carolyn A. (2014) Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family. Proceedings of the National Academy of Sciences of the United States of America 111 (5), pp. 1837-1842. ISSN 0027-8424.

    Randall, T.S. and Moores, Carolyn A. and Stephenson, F.A. (2013) Delineation of the TRAK binding regions of the kinesin-1 motor proteins. FEBS Letters 587 (23), pp. 3763-3769. ISSN 1873-3468.

    Atherton, Joseph and Houdusse, A. and Moores, Carolyn A. (2013) MAPping out distribution routes for kinesin couriers. Biology of the Cell 105 (10), pp. 465-487. ISSN 0248-4900.

    Muretta, J.M. and Behnke-Parks, W.M. and Major, J. and Petersen, K.J. and Goulet, A. and Moores, Carolyn A. and Thomas, D.D. and Rosenfeld, S.S. (2013) Loop L5 assumes three distinct orientations during the ATpase cycle of the mitotic kinesin eg5: a transient and time-resolved flourescence study. Journal of Biological Chemistry 288 (48), pp. 34839-34849. ISSN 0021-9258.

    Bahi-Buisson, N. and Souville, I. and Fourniol, Franck J. and Toussaint, A. and Moores, Carolyn A. and Houdusse, A. and Yves Lemaitre, J. and Poirier, K. and Khalaf-Nazzal, R. and Hully, M. and Louis Leger, P. and Elie, C. and Boddaert, N. and Beldjord, C. and Chelly, J. and Francis, F. (2013) New insights into genotype-phenotype correlations for the doublecortin-related lissencephaly spectrum. Brain 136 (1), pp. 223-244. ISSN 1460-2156.

    Goulet, Adeline and Behnke-Parks, W.M. and Sindelar, C.V. and Major, J. and Rosenfeld, S.S. and Moores, Carolyn A. (2012) The structural basis of force generation by the Mitotic motor Kinesin-5. Journal of Biological Chemistry 287 , pp. 44654-44666. ISSN 0021-9258.

    Moores, Carolyn A. (2012) Dynein: a force (generation mechanism) to be reckoned with. Structure 20 (10), pp. 1611-1612. ISSN 0969-2126.

    Liu, J.S. and Schubert, C.R. and Fu, X. and Fourniol, Franck J. and Jaiswal, J.K. and Houdusse, A. and Stultz, C.M. and Moores, Carolyn A. and Walsh, C.A. (2012) Molecular basis for specific regulation of neuronal Kinesin-3 motors by Doublecortin family proteins. Molecular Cell 47 (5), pp. 707-721. ISSN 1097-2765.

    Maurer, S.P. and Fourniol, Franck J. and Bohner, G. and Moores, Carolyn A. and Surrey, T. (2012) EBs recognize a nucleotide-dependent structural cap at growing microtubule ends. Cell 149 (2), pp. 371-382. ISSN 0092-8674.

    Moores, Carolyn A. and Peters, Carsten and Brejc, K. and Belmont, L. and Bodey, Andrew J. and Lee, Y. and Yu, M. and Guo, J. and Sakowicz, R. and Hartman, J. (2011) Small loops make a big difference: insight into the molecular mechanism of the multi-tasking Kinesin-8 Motor. Biophysical Journal 100 (3), 3a-3a. ISSN 0006-3495.

    Behnke-Parks, W.M. and Vendome, J. and Honig, B. and Maliga, Z. and Moores, Carolyn A. and Rosenfeld, S.S. (2011) Loop L5 acts as a conformational latch in the Mitotic Kinesin Eg5. Journal of Biological Chemistry 286 (7), pp. 5242-5253. ISSN 0021-9258.

    Fourniol, Franck J. and Moores, Carolyn A. (2011) Snapshots of kinesin motors on microtubule tracks. Methods in Molecular Biology 778 , pp. 57-70. ISSN 1064-3745.

    Fourniol, Franck J. and Sindelar, C.V. and Amigues, B. and Clare, Daniel K. and Thomas, G. and Perderiset, M. and Francis, F. and Houdusse, A. and Moores, Carolyn A. (2010) Template-free 13-protofilament microtubule–MAP assembly visualized at 8 A resolution. The Journal of Cell Biology 191 (3), pp. 463-470. ISSN 0021-9525.

    Moores, Carolyn A. (2010) Kinesin-5 mitotic motors: is loop5 the on/off switch? Cell Cycle 9 (7), pp. 1286-1290. ISSN 1551-4005.

    Fourniol, Franck J. and Moores, Carolyn A. (2010) Kinesin motor activation: microtubules pull the switches. Proceedings of the National Academy of Sciences of the United States of America 107 (9), pp. 3949-3950. ISSN 0027-8424.

    Peters, Carsten and Brejc, K. and Belmont, L. and Bodey, Andrew J. and Lee, Y. and Yu, M. and Ramchandani, S. and Guo, J. and Lichtsteiner, S. and Wood, K. and Sakowicz, R. and Hartman, J. and Moores, Carolyn A. (2010) The molecular mechanism of the multi-tasking Kinesin-8 motor. Biophysical Journal 98 (3(S1)), 166a-166a. ISSN 0006-3495.

    Peters, Carsten and Brejc, K. and Belmont, L. and Bodey, Andrew J. and Lee, Y. and Yu, M. and Guo, J. and Sakowicz, R. and Hartman, J. and Moores, Carolyn A. (2010) Insight into the molecular mechanism of the multitasking kinesin-8 motor. The EMBO Journal 29 (20), pp. 3437-3447. ISSN 0261-4189.

    Bodey, Andrew J. and Kikkawa, M. and Moores, Carolyn A. (2009) 9-Angström structure of a microtubule-bound mitotic motor. Journal of Molecular Biology 388 (2), pp. 218-224. ISSN 0022-2836.

    Mulder, A.M. and Glavis-Bloom, A. and Moores, Carolyn A. and Wagenbach, M. and Carragher, B. and Wordeman, L. and Milligan, R.A. (2009) A new model for binding of kinesin 13 to curved microtubule protofilaments. Journal of Cell Biology 185 (1), pp. 51-57. ISSN 0021-9525.

    Bodey, Andrew J. and Kikkawa, M. and Moores, Carolyn A. (2009) The ATP state of a mitotic Kinesin-5 bound to microtubules. Biophysical Journal 96 (3(S1)), 215a-215a. ISSN 0006-3495.

    Ciferri, C. and Pasqualato, S. and Screpanti, E. and Varetti, G. and Santaguida, S. and dos Reis, G. and Maiolica, A. and Polka, J. and de Luca, J.G. and de Wulf, P. and Salek, M. and Rappsilber, J. and Moores, Carolyn A. and Salmon, E.D. and Musacchio, A. (2008) Implications for Kinetochore-Microtubule attachment from the structure of an engineered Ndc80 complex. Cell 133 (3), pp. 427-439. ISSN 0092-8674.

    Moores, Carolyn A. and Milligan, R.A. (2008) Visualisation of a kinesin-13 motor on microtubule end mimics. Journal of Molecular Biology 377 (3), pp. 647-654. ISSN 0022-2836.

    Moores, Carolyn A. (2008) Studying microtubules by electron microscopy. Introduction to Electron Microscopy for Biologists 88 , pp. 299-317. ISSN 0091-679X.

    Moores, Carolyn A. and Milligan, R.A. (2006) Lucky 13-microtubule depolymerisation by kinesin-13 motors. Journal of Cell Science 119 (Pt 19), pp. 3905-13. ISSN 0021-9533.

    Book Section

    Manka, Szymon and Moores, Carolyn A. (2019) Cryo-TEM and Biological Structure Determination. In: Ramesh, V. (ed.) Biomolecular and Bioanalytical Techniques: Theory, Methodology and Applications. John Wiley & Sons, Ltd, pp. 471-499. ISBN 9781119483960.

    Goulet, Adeline and Moores, Carolyn A. (2013) New insights into the mechanism of force generation by Kinesin-5 molecular motors. In: Jeon, K.W. (ed.) International Review of Cell and Molecular Biology. New York, U.S.: Elsevier, pp. 419-466. ISBN 9780124076969.

    Fourniol, Franck J. and Perderiset, M. and Houdusse, A. and Moores, Carolyn A. (2013) Structural studies of the Doublecortin family of MAPs. In: Correia, J.J. and Wilson, L. (eds.) Microtubules, In Vitro (2nd Edition). Methods In Cell Biology 115. New York, U.S.: Elsevier, pp. 27-48. ISBN 9780124077577.

    This list was generated on Wed Jun 26 03:21:57 2019 BST.