Article

Muselmani, Wael and Kashif-Khan, Naail and Bagneris, Claire and Santangelo, Rosalia and Williams, Mark A and Savva, Renos (2023) A multimodal approach towards genomic identification of protein inhibitors of Uracil-DNA Glycosylase. Viruses 15 (6), ISSN 1999-4915.

Javed, Abid and Villanueva, Hugo and Shataer, S. and Vasciaveo, S. and Savva, Renos and Orlova, Elena (2021) Cryo-EM structures of two Bacteriophage portal proteins provide insights for antimicrobial phage engineering. Viruses 13 (12), ISSN 1999-4915.

Savva, Renos (2020) The essential co-option of Uracil-DNA Glycosylases by Herpesviruses invites novel antiviral design. Microorganisms 8 (3), p. 461. ISSN 2076-2607.

Savva, Renos (2019) Targeting uracil-DNA glycosylases for therapeutic outcomes using insights from virus evolution. Future Medicinal Chemistry 11 (11), ISSN 1756-8919.

Earl, Chris and Bagneris, Claire and Zeman, K. and Cole, Ambrose and Barrett, Tracey and Savva, Renos (2018) A structurally conserved motif in γ-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping. Nucleic Acids Research 46 (8), pp. 4286-4300. ISSN 0305-1048.

Cole, Ambrose R. and Ofer, Sapir and Ryzhenkova, Ksenia and Baltulionis, Gediminas and Hornyak, Peter and Savva, Renos (2013) Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase. Nucleic Acids Research 41 (18), pp. 8760-8775. ISSN 0305-1048.

Meier, C. and Brookings, D.C. and Ceska, T.A. and Doyle, C. and Gong, H. and McMillan, D. and Saville, G.P. and Mushtaq, A. and Knight, D. and Reich, S. and Pearl, L.H. and Powell, K.A. and Savva, Renos and Allen, R.A. (2012) Engineering human MEK-1 for structural studies: a case study of combinatorial domain hunting. Journal of Structural Biology 177 (2), pp. 329-334. ISSN 1047-8477.

Fogl, C. and Puckey, Loretto and Hinssen, U. and Zaleska, M. and el-Mezgueldi, M. and Croasdale, R. and Bowman, A. and Matsukawa, A. and Samani, N.J. and Savva, Renos and Pfuhl, M. (2012) A structural and functional dissection of the cardiac stress response factor MS1. Proteins: Structure, Function, and Bioinformatics 80 (2), pp. 398-409. ISSN 0887-3585.

Bagneris, Claire and Briggs, Louise C. and Savva, Renos and Ebrahimi, B. and Barrett, Tracey E. (2011) Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff. Nucleic Acids Research 39 (13), pp. 5744-5756. ISSN 0305-1048.

Maclagan, K. and Tommasi, R. and Laurine, E. and Prodromou, C. and Driscoll, P.C. and Pearl, L.H. and Reich, S. and Savva, Renos (2011) A combinatorial method to enable detailed investigation of protein-protein interactions. Future Medicinal Chemistry 3 (3), pp. 271-282. ISSN 1756-8919.

Savva, Renos and Prodromou, C. and Driscoll, P.C. (2007) DNA fragmentation based combinatorial approaches to soluble protein expression: part II: library expression, screening and scale-up. Drug Discovery Today 12 (21-22), pp. 939-947. ISSN 1359-6446.

Prodromou, C. and Savva, Renos and Driscoll, P.C. (2007) DNA fragmentation-based combinatorial approaches to soluble protein expression: part I: generating DNA fragment libraries. Drug Discovery Today 12 (21-22), pp. 931-938. ISSN 1359-6446.

Reich, S. and Puckey, L.H. and Cheetham, C.L. and Harris, R. and Ali, A.A. and Bhattacharyya, U. and Maclagan, K. and Powell, K.A. and Prodromou, C. and Pearl, L.H. and Driscoll, P.C. and Savva, Renos (2006) Combinatorial domain hunting: an effective approach for the identification of soluble protein domains adaptable to high-throughput applications. Protein Science 15 (10), pp. 2356-2365. ISSN 0961-8368.

dos Reis, M. and Savva, Renos and Wernisch, Lorenz (2004) Solving the riddle of codon usage preferences: a test for translational selection. Nucleic Acids Research 32 (17), pp. 5036-5044. ISSN 0305-1048.

dos Reis, M. and Wernisch, Lorenz and Savva, Renos (2003) Unexpected correlations between gene expression and codon usage bias from microarray data for the whole Escherichia coli K-12 genome. Nucleic Acids Research 31 (23), pp. 6976-6985. ISSN 0305-1048.

Bunting KA and Roe SM and Headley A and Brown T and Savva, Renos and Pearl LH (2003) Crystal structure of the escherichia coli dcm very-short-patch DNA repair endonuclease bound to its reaction product-site in a DNA superhelix. Nucleic Acids Research 31 (6), pp. 1633-1639. ISSN 0305-1048.

Rösler A and Panayotou G and Hornby DP and Barlow T and Brown T and Pearl LH and Savva, Renos and Blackburn GM (2000) The mechanism of DNA repair by uracil-DNA glycosylase: studies using nucleotide analogues. Nucleosides, Nucleotides and Nucleic Acids 19 (10-12), pp. 1505-1516. ISSN 1525-7770.

Barrett, T.E. and Schärer, O.D. and Savva, Renos and Brown, T. and Jiricny, J. and Verdine, G.L. and Pearl, L.H. (1999) Crystal structure of a thwarted mismatch glycosylase DNA repair complex. Embo Journal 18 (23), pp. 6599-6609. ISSN 0261-4189.

Barrett, T.E. and Savva, Renos and Panayotou, G. and Barlow, T. and Brown, T. and Jiricny, J. and Pearl, L.H. (1998) Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions. Cell 92 (1), pp. 117-129. ISSN 0092-8674.

Panayotou, G. and Brown, T. and Barlow, T. and Pearl, L.H. and Savva, Renos (1998) Direct measurement of the substrate preference of uracil-DNA glycosylase. Journal of Biological Chemistry 273 (1), pp. 45-50. ISSN 0021-9258.

Barrett, T.E. and Savva, Renos and Barlow, T. and Brown, T. and Jiricny, J. and Pearl, L.H. (1998) Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct. Nature Structural Biology 5 (8), pp. 697-701. ISSN 1072-8368.

Koulis, A. and Cowan, D.A. and Pearl, L.H. and Savva, Renos (1996) Uracil-DNA glycosylase activities in hyperthermophilic micro-organisms. FEMS Microbiology Letters 143 (2-3), pp. 267-271. ISSN 0378-1097.

Pearl, L.H. and Savva, Renos (1996) The problem with Pyrimidines. Nature Structural Biology 3 (6), pp. 485-487. ISSN 1072-8368.

Savva, Renos and Pearl, L.H. (1995) Cloning and expression of the uracil-DNA glycosylase inhibitor (UGI) from bacteriophage PBS-1 and crystallization of a uracil-DNA glycosylase-UGI complex. Proteins: Structure, Function, and Bioinformatics 22 (3), pp. 287-289. ISSN 0887-3585.

Pearl, L.H. and Savva, Renos (1995) DNA repair in three dimensions. Trends in Biochemical Sciences 20 (10), pp. 421-426. ISSN 0968-0004.

Savva, Renos and Pearl, L.H. (1995) Nucleotide mimicry in the crystal structure of the uracil-DNA glycosylase-uracil glycosylase inhibitor protein complex. Nature Structural Biology 2 (9), pp. 752-757. ISSN 1072-8368.

Savva, Renos and McAuley-Hecht, K. and Brown, T. and Pearl, L. (1995) The structural basis of specific base-excision repair by uracil-DNA glycosylase. Nature 373 (6514), pp. 487-493. ISSN 0028-0836.

Savva, Renos and Pearl, L.H. (1993) Crystallization and preliminary X-ray analysis of the uracil-DNA glycosylase DNA repair enzyme from herpes simplex virus type 1. Journal of Molecular Biology 234 (3), pp. 910-912. ISSN 0022-2836.