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Protein kinase C intervention: the state of play

Roffey, J. and Rosse, C. and Linch, M. and Hibbert, A. and McDonald, Neil Q. and Parker, P.J. (2009) Protein kinase C intervention: the state of play. Current Opinion in Cell Biology 21 (2), pp. 268-279. ISSN 1879-0410.

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Abstract

Intervention in protein kinase C (PKC) has a chequered history, partly because of the poor selectivity of many inhibitors and partly a reflection of the sometimes antagonistic action of related PKC isoforms. Recent advances in targeting PKC isoforms have come from structural work on isolated kinase domains that have provided opportunities to drive selectivity through structure-based avenues. The promise of isoform selective inhibitors and the rationale for their development are discussed in the broader context of the PKC inhibitor arsenal.

Metadata

Item Type: Article
School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
Depositing User: Administrator
Date Deposited: 04 Aug 2010 14:09
Last Modified: 02 Aug 2023 16:49
URI: https://eprints.bbk.ac.uk/id/eprint/1033

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