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    Making connections: snapshots of chlamydial type III secretion systems in contact with host membranes

    Dumoux, Maud and Nans, Andrea and Saibil, Helen R. and Hayward, Richard D. (2015) Making connections: snapshots of chlamydial type III secretion systems in contact with host membranes. Current Opinion in Microbiology 23 , pp. 1-7. ISSN 1369-5274.

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    Abstract

    Chlamydiae are obligate intracellular bacterial pathogens with an unusual biphasic lifecycle, which is underpinned by two bacterial forms of distinct structure and function. Bacterial entry and replication require a type III secretion system (T3SS), a widely conserved nanomachine responsible for the translocation of virulence effectors into host cells. Recent cell biology experiments supported by electron and cryo-electron tomography have provided fresh insights into Chlamydia–host interactions. In this review, we highlight some of the recent advances, particularly the in situ analysis of T3SSs in contact with host membranes during chlamydial entry and intracellular replication, and the role of the host rough endoplasmic reticulum (rER) at the recently described intracellular ‘pathogen synapse’.

    Metadata

    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Research Centre: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 27 Oct 2014 08:25
    Last Modified: 28 Jul 2019 18:51
    URI: http://eprints.bbk.ac.uk/id/eprint/10786

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