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    Fragment library design considerations

    Boyd, S.M. and Turnbull, Andrew P. and Walse, B. (2012) Fragment library design considerations. Wiley Interdisciplinary Reviews: Computational Molecular Science 2 (6), pp. 868-885. ISSN 1759-0876.

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    As fragment-based drug design has become established as a standard component of the drug discovery armory, the design of fragment libraries has evolved according to the practicalities of detection methods, synthetic elaboration, and intended use of the libraries. Through experience, several companies have iteratively designed and redesigned their fragment libraries to these ends, and have reported their findings to aid in future library design. Here, some of these libraries are described and various empirical design considerations are reviewed. Design criteria for future directions in fragment library design are considered, such as targeting of membrane-bound targets or disruption of protein–protein interactions.


    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Depositing User: Administrator
    Date Deposited: 26 Nov 2014 13:51
    Last Modified: 26 Nov 2014 13:51


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