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    Repurposing — a ray of hope in tackling extensively drug resistance in tuberculosis

    Maitra, A. and Bates, S. and Kolvekar, T. and Devarajan, P.V. and Guzman, Juan D. and Bhakta, Sanjib (2015) Repurposing — a ray of hope in tackling extensively drug resistance in tuberculosis. International Journal of Infectious Diseases 32 , pp. 50-55. ISSN 1201-9712.

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    Abstract

    Tuberculosis (TB) remains a serious concern more than two decades on from when the World Health Organization declared it a global health emergency. The alarming rise of antibiotic resistance in Mycobacterium tuberculosis, the etiological agent of TB, has made it exceedingly difficult to control the disease with the existing portfolio of anti-TB chemotherapy. The development of effective drugs with novel mechanism(s) of action is thus of paramount importance to tackle drug resistance. The development of novel chemical entities requires more than 10 years of research, requiring high-risk investment to become commercially available. Repurposing pre-existing drugs offers a solution to circumvent this mammoth investment in time and funds. In this context, several drugs with known safety and toxicity profiles have been evaluated against the TB pathogen and found to be efficacious against its different physiological states. As the endogenous targets of these drugs in the TB bacillus are most likely to be novel, there is minimal chance of cross-resistance with front-line anti-TB drugs. Also, reports that some of these drugs may potentially have multiple targets means that the possibility of the development of resistance against them is minimal. Thus repurposing existing molecules offers immense promise to tackle extensively drug-resistant TB infections.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Tuberculosis (TB), Mycobacterium tuberculosis, Antibiotic resistance, Repurposing, Repositioning, Whole-cell phenotypic screening
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Research Centre: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 23 Mar 2015 15:03
    Last Modified: 30 Jul 2019 05:11
    URI: http://eprints.bbk.ac.uk/id/eprint/11855

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