Integrative modelling of cellular assemblies

Joseph, Agnel Praveen and Polles, G. and Alber, F. and Topf, Maya (2017) Integrative modelling of cellular assemblies. Current Opinion in Structural Biology 46 , pp. 102-109. ISSN 0959-440X.

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Official URL: https://doi.org/10.1016/j.sbi.2017.07.001

Abstract

A wide variety of experimental techniques can be used for understanding the precise molecular mechanisms underlying the activities of cellular assemblies. The inherent limitations of a single experimental technique often requires integration of data from complementary approaches to gain sufficient insights into the assembly structure and function. Here, we review popular computational approaches for integrative modelling of cellular assemblies, including protein complexes and genomic assemblies. We provide recent examples of integrative models generated for such assemblies by different experimental techniques, especially including data from 3D electron microscopy (3D-EM) and chromosome conformation capture experiments, respectively. We highlight general concepts in integrative modelling and discuss the need for careful formulation and merging of different types of information.

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Item Type:	Article
School:	Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
Depositing User:	Administrator
Date Deposited:	14 Aug 2017 13:43
Last Modified:	02 Aug 2023 17:34
URI:	https://eprints.bbk.ac.uk/id/eprint/19384

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