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    A light-activated antimicrobial surface is active against bacterial, viral and fungal organisms

    Walker, T. and Canales, M. and Noimark, S. and Page, K. and Parkin, I. and Nicklin, Jane and Bhatti, M. and Ciric, L. (2017) A light-activated antimicrobial surface is active against bacterial, viral and fungal organisms. Scientific Reports 7 (1), ISSN 2045-2322.

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    Abstract

    Evidence has shown that environmental surfaces play an important role in the transmission of nosocomial pathogens. Deploying antimicrobial surfaces in hospital wards could reduce the role environmental surfaces play as reservoirs for pathogens. Herein we show a significant reduction in viable counts of Staphylococcus epidermidis, Saccharomyces cerevisiae, and MS2 Bacteriophage after light treatment of a medical grade silicone incorporating crystal violet, methylene blue and 2 nm gold nanoparticles. Furthermore, a migration assay demonstrated that in the presence of light, growth of the fungus-like organism Pythium ultimum and the filamentous fungus Botrytis cinerea was inhibited. Atomic Force Microscopy showed significant alterations to the surface of S. epidermidis, and electron microscopy showed cellular aggregates connected by discrete surface linkages. We have therefore demonstrated that the embedded surface has a broad antimicrobial activity under white light and that the surface treatment causes bacterial envelope damage and cell aggregation.

    Metadata

    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Depositing User: Administrator
    Date Deposited: 12 Jan 2018 14:08
    Last Modified: 28 Jul 2019 04:22
    URI: http://eprints.bbk.ac.uk/id/eprint/20678

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