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    The relationship between anticipated response and subsequent experience of cancer treatment-related side effects: a meta-analysis comparing effects before and after treatment exposure

    Fletcher, C. and Wilson, C. and Hutchinson, A. and Grunfeld, Elizabeth (2018) The relationship between anticipated response and subsequent experience of cancer treatment-related side effects: a meta-analysis comparing effects before and after treatment exposure. Cancer Treatment Reviews 68 , pp. 86-93. ISSN 0305-7372.

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    Abstract

    Objective: To review the evidence for a systematic relationship between cancer patients’ pre-treatment expectations (anticipated side effects) and subsequent experience of treatment-related side effects, and to compare this relationship in patients with no prior treatment experience (cognitive expectations) and with some prior treatment experience (conditioned response). Methods: A total of 12,952 citations were identified through a comprehensive search of the literature published on or before November 2016 and screened against inclusion criteria. Studies were eligible if they included participants undergoing curative treatment for cancer, measured a treatment side effect, examined the relationship between anticipation and experience of side effects, and reported quantitative data. Results: Thirty-one studies were included in the review and meta-analysis (total N = 5,069). The side effects examined were nausea (anticipatory and post-treatment), vomiting, fatigue, pain, problems with concentration, and skin reactions. Meta-analyses indicated significant and positive associations between anticipation and subsequent experience for all included side effects in patients with no prior treatment exposure (r = 0.153 – 0.431). Stronger associations were found for all included conditioned side effects in patients with previous treatment experience (r = 0.211 – 0.476). No significant differences were found when overall effect sizes for patients with and without prior treatment exposure were compared for each side effect, except for anticipatory nausea (p = 0.012). Conclusion: These results may have implications for future interventions that target patients’ expectations of cancer treatment-related side effects. Future research could explore patient reports of messages received about likely treatment effects both before and during treatment.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Cancer, Cancer treatment, Conditioning, Expectancies, Expectancy, Side effects
    School: Birkbeck Schools and Departments > School of Science > Psychological Sciences
    Depositing User: Beth Grunfeld
    Date Deposited: 25 Jun 2018 10:17
    Last Modified: 25 Jun 2020 20:31
    URI: http://eprints.bbk.ac.uk/id/eprint/22858

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