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    Genome-wide association study of latent cognitive measures in adolescence: genetic overlap with intelligence and education

    Donati, Georgina and Dumontheil, Iroise and Meaburn, Emma (2019) Genome-wide association study of latent cognitive measures in adolescence: genetic overlap with intelligence and education. Mind, Brain, and Education 13 (3), pp. 224-233. ISSN 1751-2271.

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    Abstract

    Individual differences in executive functions (EF) are heritable and predictive of academic attainment (AA). However, little is known about genetic contributions to EFs or their genetic relationship with AA and intelligence. We conducted genome-wide association analyses for processing speed (PS) and the latent EF measures of working memory (WM) and inhibitory control (IC) in 4,611 adolescents from ALSPAC. Whilst no loci reached genome-wide significance, common genetic variants explained 30% of the variance in WM and 19% in PS. In contrast, we failed to find common genetic contributions to IC. Finally, we examined shared genetic effects between EFs, and general intelligence, AA and ADHD. We identified significant genetic correlations between WM, intelligence and AA. A more specific pattern was observed for PS, with modest genetic overlap with intelligence. Together these findings highlight diversity in the genetic contributions to specific cognitive functions and their genetic relationship with educational and psychiatric outcomes

    Metadata

    Item Type: Article
    Additional Information: This is the peer reviewed version of the article, which has been published in final form at the link above. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    Keyword(s) / Subject(s): Genome-wide association, Genetics, Adolescence, Cognition, Education, Executive Function, ALSPAC
    School: Birkbeck Schools and Departments > School of Science > Psychological Sciences
    Research Centre: Educational Neuroscience, Centre for
    Depositing User: Emma Meaburn
    Date Deposited: 30 Apr 2019 11:49
    Last Modified: 18 Feb 2020 23:12
    URI: http://eprints.bbk.ac.uk/id/eprint/27242

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