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    FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides

    Ornitz, D. and Herr, A. and Nillson, M. and Westman, J. and Svahn, C.-M. and Waksman, Gabriel (1995) FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides. Science 268 (5209), pp. 432-436. ISSN 0036-8075.

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    Abstract

    Fibroblast growth factors (FGFs) require a polysaccharide cofactor, heparin or heparan sulfate (HS), for receptor binding and activation. To probe the molecular mechanism by which heparin or HS (heparin/HS) activates FGF, small nonsulfated oligosaccharides found within heparin/HS were assayed for activity. These synthetic and isomerically pure compounds can activate the FGF signaling pathway. The crystal structures of complexes between FGF and these heparin/HS oligosaccharides reveal several binding sites on FGF and constrain possible mechanisms by which heparin/HS can activate the FGF receptor. These studies establish a framework for the molecular design of compounds capable of modulating FGF activity.

    Metadata

    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Depositing User: Sarah Hall
    Date Deposited: 29 Apr 2019 15:37
    Last Modified: 29 Apr 2019 15:37
    URI: http://eprints.bbk.ac.uk/id/eprint/27351

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