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    Conserved Central Intraviral Protein Interactome of the Herpesviridae Family

    Hernández Durán, A. and Grünewald, K. and Topf, Maya and Kristie, T.M. (2019) Conserved Central Intraviral Protein Interactome of the Herpesviridae Family. mSystems 4 (5), e00295-19. ISSN 2379-5077.

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    Abstract

    Protein interactions are major driving forces behind the functional phenotypes of biological processes. As such, evolutionary footprints are reflected in system-level collections of protein-protein interactions (PPIs), i.e., protein interactomes. We conducted a comparative analysis of intraviral protein interactomes for representative species of each of the three subfamilies of herpesviruses (herpes simplex virus 1, human cytomegalovirus, and Epstein-Barr virus), which are highly prevalent etiologic agents of important human diseases. The intraviral interactomes were reconstructed by combining experimentally supported and computationally predicted protein-protein interactions. Using cross-species network comparison, we then identified family-wise conserved interactions and protein complexes, which we defined as a herpesviral “central” intraviral protein interactome. A large number of widely accepted conserved herpesviral protein complexes are present in this central intraviral interactome, encouragingly supporting the biological coherence of our results. Importantly, these protein complexes represent most, if not all, of the essential steps required during a productive life cycle. Hence the central intraviral protein interactome could plausibly represent a minimal infectious interactome of the herpesvirus family across a variety of hosts. Our data, which have been integrated into our herpesvirus interactomics database, HVint2.0, could assist in creating comprehensive system-level computational models of this viral lineage.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): herpesviruses, intraviral network, protein-protein interactions, systems biology
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Depositing User: Administrator
    Date Deposited: 07 Oct 2019 12:59
    Last Modified: 10 Oct 2019 04:23
    URI: http://eprints.bbk.ac.uk/id/eprint/29342

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