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    A double blind controlled study of high-dose L-Deprenyl in the treatment of Parkinson's disease

    Frankel, J.P. and Kempster, P.A. and Stibe, C.M.H. and Eatough, Virginia and Nathanson, M. and Lees, A.J. and Stern, G. (1989) A double blind controlled study of high-dose L-Deprenyl in the treatment of Parkinson's disease. Clinical Neuropharmacology 12 (5), pp. 448-451. ISSN 0362-5664.

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    Abstract

    The conventional dose of deprenyl used in Parkinson's disease is 10 mg/day, having been established by in vitro platelet studies and clinical evaluation. Twelve patients with Parkinson's disease on treatment with L-dopa who showed evidence of wearing-off effects or motor oscillation were studied in a double-blind, placebo-controlled, crossover trial to compare conventional doses of deprenyl with higher doses (up to 40 mg/day) and placebo. We did not find higher doses of deprenyl to be superior to conventional doses and in 17% of cases treatment had to be withdrawn because of side effects.

    Metadata

    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Psychological Sciences
    Depositing User: Sarah Hall
    Date Deposited: 25 Nov 2019 16:11
    Last Modified: 25 Nov 2019 16:11
    URI: http://eprints.bbk.ac.uk/id/eprint/30061

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