BIROn - Birkbeck Institutional Research Online

    Synthetic genetic polymers capable of heredity and evolution

    Pinheiro, Vitor B. and Taylor, A.I. and Cozens, C. and Abramov, M. and Renders, M. and Zhang, S. and Chaput, J.C. and Wengel, J. and Peak-Chew, S.-Y. and McLaughlin, S.H. and Herdewijn, P. and Holliger, P. (2012) Synthetic genetic polymers capable of heredity and evolution. Science 336 (6079), pp. 341-344. ISSN 0036-8075.

    Full text not available from this repository.

    Abstract

    Genetic information storage and processing rely on just two polymers, DNA and RNA, yet whether their role reflects evolutionary history or fundamental functional constraints is currently unknown. With the use of polymerase evolution and design, we show that genetic information can be stored in and recovered from six alternative genetic polymers based on simple nucleic acid architectures not found in nature [xeno-nucleic acids (XNAs)]. We also select XNA aptamers, which bind their targets with high affinity and specificity, demonstrating that beyond heredity, specific XNAs have the capacity for Darwinian evolution and folding into defined structures. Thus, heredity and evolution, two hallmarks of life, are not limited to DNA and RNA but are likely to be emergent properties of polymers capable of information storage.

    Metadata

    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Research Centre: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Sarah Hall
    Date Deposited: 04 Feb 2014 10:48
    Last Modified: 06 Dec 2016 11:17
    URI: http://eprints.bbk.ac.uk/id/eprint/9150

    Statistics

    Downloads
    Activity Overview
    0Downloads
    139Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item