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    Bacterial surface appendages as targets for novel antibacterial therapeutics

    Steadman, David and Lo, A. and Waksman, Gabriel and Remaut, H. (2014) Bacterial surface appendages as targets for novel antibacterial therapeutics. Future Microbiology 9 (7), pp. 887-900. ISSN 1746-0913.

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    The rise of multidrug resistant bacteria is a major worldwide health concern. There is currently an unmet need for the development of new and selective antibacterial drugs. Therapies that target and disarm the crucial virulence factors of pathogenic bacteria, while not actually killing the cells themselves, could prove to be vital for the treatment of numerous diseases. This article discusses the main surface architectures of pathogenic Gram-negative bacteria and the small molecules that have been discovered, which target their specific biogenesis pathways and/or actively block their virulence. The future perspective for the use of antivirulence compounds is also assessed.


    Item Type: Article
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 03 Sep 2014 12:53
    Last Modified: 02 Aug 2023 17:12


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