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    Crystallization and preliminary crystallographic analysis of theClostridium perfringensenterotoxin

    Briggs, D.C. and Smedley, J.G. and McClane, B.A. and Basak, Ajit K. (2010) Crystallization and preliminary crystallographic analysis of theClostridium perfringensenterotoxin. Acta Crystallographica Section F 66 (7), pp. 794-797. ISSN 1744-3091.

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    Clostridium perfringens is a Gram-positive anaerobic species of bacterium that is notable for its ability to produce a plethora of toxins, including membrane-active toxins ([alpha]-toxins), pore-forming toxins ([epsilon]-toxins) and binary toxins ([iota]-toxins). Here, the crystallization of the full-length wild-type C. perfringens enterotoxin is reported, which is the causative agent of the second most prevalent food-borne illness in the United States and has been implicated in many other gastrointestinal pathologies. Several crystal forms were obtained. However, only two of these optimized crystal forms (I and II) were useable for X-ray diffraction data collection. The form I crystals diffracted to dmin = 2.7 Å and belonged to space group C2, while the form II crystals diffracted to dmin = 4 Å and belonged to space group P213.


    Item Type: Article
    Keyword(s) / Subject(s): pore-forming toxins, enterotoxins, Clostridium perfringens
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Depositing User: Administrator
    Date Deposited: 15 Dec 2014 11:38
    Last Modified: 02 Aug 2023 17:14


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