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    The structural biology of type IV secretion systems

    Fronzes, Remi and Christie, P.J. and Waksman, Gabriel (2009) The structural biology of type IV secretion systems. Nature Reviews Microbiology 7 (10), pp. 703-714. ISSN 1740-1526.

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    Type IV secretion systems (T4SSs) are versatile secretion systems that are found in both Gram-negative and Gram-positive bacteria and secrete a wide range of substrates, from single proteins to protein–protein and protein–DNA complexes. They usually consist of 12 components that are organized into ATP-powered, double-membrane-spanning complexes. The structures of single soluble components or domains have been solved, but an understanding of how these structures come together has only recently begun to emerge. This Review focuses on the structural advances that have been made over the past 10 years and how the corresponding structural insights have helped to elucidate many of the details of the mechanism of type IV secretion.


    Item Type: Article
    Additional Information: *Former research assistant, no details (PR 4.10.11)
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 04 Aug 2010 14:09
    Last Modified: 02 Aug 2023 16:49


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