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    Ordered and ushered; the assembly and translocation of the adhesive Type I and P Pili

    Lillington, James and Waksman, Gabriel (2013) Ordered and ushered; the assembly and translocation of the adhesive Type I and P Pili. Biology 2 (3), pp. 841-860. ISSN 2079-7737.

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    Type I and P pili are chaperone-usher pili of uropathogenic Escherichia coli, which allow bacteria to adhere to host cell receptors. Pilus formation and secretion are orchestrated by two accessory proteins, a chaperone, which catalyses pilus subunit folding and maintains them in a polymerization-competent state, and an outer membrane-spanning nanomachine, the usher, which choreographs their assembly into a pilus and drives their secretion through the membrane. In this review, recent structures and kinetic studies are combined to examine the mechanism of type I and P pili assembly, as it is currently known. We also investigate how the knowledge of pilus biogenesis mechanisms has been exploited to design selective inhibitors of the process.


    Item Type: Article
    Keyword(s) / Subject(s): chaperone-usher pathway, type I and P pilus, chaperone, usher, donor-strand complementation, donor-strand exchange, pilicide
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 17 Mar 2015 12:31
    Last Modified: 02 Aug 2023 17:15


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