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    Structural biology of the Gram-negative bacterial conjugation systems

    Ilangovan, Aravindan and Connery, Sarah and Waksman, Gabriel (2015) Structural biology of the Gram-negative bacterial conjugation systems. Trends in Microbiology 23 (5), pp. 301-310. ISSN 0966-842X.

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    Conjugation, the process by which plasmid DNA is transferred from one bacterium to another, is mediated by type IV secretion systems (T4SSs). T4SSs are versatile systems that can transport not only DNA, but also toxins and effector proteins. Conjugative T4SSs comprise 12 proteins named VirB1–11 and VirD4 that assemble into a large membrane-spanning exporting machine. Before being transported, the DNA substrate is first processed on the cytoplasmic side by a complex called the relaxosome. The substrate is then targeted to the T4SS for export into a recipient cell. In this review, we describe the recent progress made in the structural biology of both the relaxosome and the T4SS.


    Item Type: Article
    Keyword(s) / Subject(s): bacterial conjugation, DNA transport, substrate secretion, Type IV secretion system, T4SS, structural biology
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 21 Apr 2015 07:38
    Last Modified: 02 Aug 2023 17:15


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