BIROn - Birkbeck Institutional Research Online

    The inheritance of acquired epigenetic variations

    Jablonka, E. and Lamb, Marion J. (2015) The inheritance of acquired epigenetic variations. International Journal of Epidemiology , ISSN 0300-5771.

    Full text not available from this repository.

    Abstract

    There is evidence that the functional history of a gene in one generation can influence its expression in the next. In somatic cells, changes in gene activity are frequently associated with changes in the pattern of methylation of the cytosines in DNA; these methylation patterns are stably inherited. Recent work suggests that information about patterns of methylation and other epigenetic states can also be transmitted from parents to offspring. This evidence is the basis of a model for the inheritance of acquired epigenetic variations. According to the model, an environmental stimulus can induce heritable chromatin modifications which are very specific and predictable, and might result in an adaptive response to the stimulus. This type of response probably has most significance for adaptive evolution in organisms such as fungi and plants, which lack distinct segregation of the soma and germ line. However, in all organisms, the accumulation of specific and random chromatin modifications in the germ line may be important in speciation, because these modifications could lead to reproductive isolation between populations. Heritable chromatin variations may also alter the frequency and distribution of classical mutations and meiotic recombination. Therefore, inherited epigenetic changes in the structure of chromatin can influence neo-Darwinian evolution as well as cause a type of “Lamarckian” inheritance.

    Metadata

    Item Type: Article
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Depositing User: Administrator
    Date Deposited: 21 Apr 2015 07:42
    Last Modified: 02 Aug 2023 17:15
    URI: https://eprints.bbk.ac.uk/id/eprint/11934

    Statistics

    Activity Overview
    6 month trend
    0Downloads
    6 month trend
    333Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item