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    Secretion systems in Gram-negative bacteria: structural and mechanistic insights

    Dias da Costa, Tiago and Felisberto-Rodrigues, Catarina and Meir, A. and Prevost, M.S. and Redzej, Adam and Trokter, Martina and Waksman, Gabriel (2015) Secretion systems in Gram-negative bacteria: structural and mechanistic insights. Nature Reviews Microbiology 13 (6), pp. 343-359. ISSN 1740-1526.

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    Bacteria have evolved a remarkable array of sophisticated nanomachines to export various virulence factors across the bacterial cell envelope. In recent years, considerable progress has been made towards elucidating the structural and molecular mechanisms of the six secretion systems (types I–VI) of Gram-negative bacteria, the unique mycobacterial type VII secretion system, the chaperone–usher pathway and the curli secretion machinery. These advances have greatly enhanced our understanding of the complex mechanisms that these macromolecular structures use to deliver proteins and DNA into the extracellular environment or into target cells. In this Review, we explore the structural and mechanistic relationships between these single- and double-membrane-embedded systems, and we briefly discuss how this knowledge can be exploited for the development of new antimicrobial strategies.


    Item Type: Article
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 19 May 2015 13:51
    Last Modified: 02 Aug 2023 17:16


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