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    Structural studies of T4S systems by electron microscopy

    Redzej, Adam and Waksman, Gabriel and Orlova, Elena (2015) Structural studies of T4S systems by electron microscopy. AIMS Biophysics 2 (2), pp. 184-199. ISSN 2377-9098.

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    Abstract: Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNA and/or proteins through the membranes of bacteria. Analysis of T4S system architecture is an extremely challenging task taking into account their multi protein organisation and lack of overall global symmetry. Nonetheless the last decade demonstrated an amazing progress achieved by X-ray crystallography and cryo-electron microscopy. In this review we present a structural analysis of this dynamic complex based on recent advances in biochemical, biophysical and structural studies.


    Item Type: Article
    School: School of Science > Biological Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 17 Jun 2015 16:17
    Last Modified: 16 Jun 2021 14:32


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