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    Conformational changes and disease — serpins, prions and Alzheimer's

    Carrell, R.W. and Gooptu, Bibek (1998) Conformational changes and disease — serpins, prions and Alzheimer's. Current Opinion in Structural Biology 8 (6), pp. 799-809. ISSN 0959-440X.

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    Some of the most perplexing disorders in medicine are each now known to arise from the conformational instability of an underlying protein. The consequence is a continuum of pathologies with typically a change in fold leading to ordered aggregation and tissue deposition. The serpins provide a structural prototype for these pathologies and give a perspective on the assessment of current proposals as to the conformational basis of both Alzheimer's disease and the transmissible prion encephalopathies.


    Item Type: Article
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 24 Jun 2015 14:45
    Last Modified: 02 Aug 2023 17:17


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