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    The structural biology of α1-antitrypsin deficiency and the serpinopathies

    Gooptu, Bibek and Lomas, David A. (2011) The structural biology of α1-antitrypsin deficiency and the serpinopathies. In: Tschesche, H. (ed.) Methods in Protein Biochemistry. Berlin, Germany: DeGruyter, pp. 325-344. ISBN 9783110252361.

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    Abstract

    Book synopsis: This book presents a survey of recent developments in protein biochemistry. Top researchers in the field of protein biochemistry describe modern methods to address the challenges of protein purification by three-phase partitioning, and their folding and degradation by the functions of chaperones. The significance of peptide purity for fibril formation is addressed as well as the use of target oriented peptide arrays in palliative approaches in mucoviszidose. The design and application of protein epitope mimetics just as the structural resolving of the misfolding of various mutant proteins in serpinopathies enlarge our tools in resolving pathophysiological imbalances.

    Metadata

    Item Type: Book Section
    School: School of Science > Biological Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 24 Jun 2015 14:44
    Last Modified: 06 Dec 2016 10:42
    URI: https://eprints.bbk.ac.uk/id/eprint/12442

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