BIROn - Birkbeck Institutional Research Online

    Autism diagnosis differentiates neurophysiological responses to faces in adults with tuberous sclerosis complex

    Tye, C. and Farroni, Teresa and Volein, Agnes and Mercure, E. and Tucker, Leslie A. and Johnson, Mark H. and Bolton, P.F. (2015) Autism diagnosis differentiates neurophysiological responses to faces in adults with tuberous sclerosis complex. Journal of Neurodevelopmental Disorders 7 (1), ISSN 1866-1947.

    [img]
    Preview
    Text
    13099.pdf - Published Version of Record
    Available under License Creative Commons Attribution.

    Download (1MB) | Preview

    Abstract

    - Background: Autism spectrum disorder (ASD) is a common and highly heritable neurodevelopmental disorder that is likely to be the outcome of complex aetiological mechanisms. One strategy to provide insight is to study ASD within tuberous sclerosis complex (TSC), a rare disorder with a high incidence of ASD, but for which the genetic cause is determined. Individuals with ASD consistently demonstrate face processing impairments, but these have not been examined in adults with TSC using event-related potentials (ERPs) that are able to capture distinct temporal stages of processing. - Methods: For adults with TSC (n = 14), 6 of which had a diagnosis of ASD, and control adults (n = 13) passively viewed upright and inverted human faces with direct or averted gaze, with concurrent EEG recording. Amplitude and latency of the P1 and N170 ERPs were measured. - Results: Individuals with TSC + ASD exhibited longer N170 latencies to faces compared to typical adults. Typical adults and adults with TSC-only exhibited longer N170 latency to inverted versus upright faces, whereas individuals with TSC + ASD did not show latency differences according to face orientation. In addition, individuals with TSC + ASD showed increased N170 latency to averted compared to direct gaze, which was not demonstrated in typical adults. A reduced lateralization was shown for the TSC + ASD groups on P1 and N170 amplitude. - Conclusions: The findings suggest that individuals with TSC + ASD may have similar electrophysiological abnormalities to idiopathic ASD and are suggestive of developmental delay. Identifying brain-based markers of ASD that are similar in TSC and idiopathic cases is likely to help elucidate the risk pathways to ASD.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Autism spectrum disorder, ERP, Face, Gaze, Tuberous sclerosis complex
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Psychological Sciences
    Research Centres and Institutes: Brain and Cognitive Development, Centre for (CBCD)
    Depositing User: Administrator
    Date Deposited: 28 Oct 2015 14:28
    Last Modified: 02 Aug 2023 17:19
    URI: https://eprints.bbk.ac.uk/id/eprint/13099

    Statistics

    Activity Overview
    6 month trend
    363Downloads
    6 month trend
    1,004Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item
    Edit/View Item