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    Membrane contact sites between pathogen-containing compartments and host organelles

    Dumoux, Maud and Hayward, Richard D. (2016) Membrane contact sites between pathogen-containing compartments and host organelles. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1861 (8(B)), pp. 895-899. ISSN 1388-1981.

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    Intracellular pathogens survive and replicate within specialised membrane-bound compartments that can be considered as pseudo-organelles. Using the obligate intracellular bacterium Chlamydia as an illustrative example, we consider the modes of lipid transport between pathogen-containing compartments and host organelles, including the formation of static membrane contact sites. We discuss how lipid scavenging can be mediated via the reprogramming of cellular transporters at these interfaces and describe recent data suggesting that pathogen effectors modulate the formation of specific membrane contacts. Further study of these emerging mechanisms is likely to yield new insights into the cell biology of lipid transport and organelle communication, which highlights potential new targets and strategies for future therapeutics.


    Item Type: Article
    Additional Information: This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim Levine and Anant K. Menon.
    Keyword(s) / Subject(s): Pathogen, Membrane contact, Organelle, Type III secretion, Lipid
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 02 Mar 2016 10:58
    Last Modified: 02 Aug 2023 17:22


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