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    Lucky 13-microtubule depolymerisation by kinesin-13 motors

    Moores, Carolyn A. and Milligan, R.A. (2006) Lucky 13-microtubule depolymerisation by kinesin-13 motors. Journal of Cell Science 119 (Pt 19), pp. 3905-13. ISSN 0021-9533.

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    Abstract

    The kinesin-13 class of motors catalyses microtubule depolymerisation by bending tubulins at microtubule ends. Depolymerisation activity is intrinsic to the kinesin-13 motor core but the activity of the core alone is very low compared with that of constructs that also contain a conserved neck sequence. The full-length dimeric motor is an efficient depolymeriser and also diffuses along the microtubule lattice, which helps it to find microtubule ends. Current evidence supports the idea of a generic mechanism for kinesin-13-catalysed depolymerisation. However, the activity of kinesin-13 motors is precisely localised and regulated in vivo to enable a wide range of cellular roles. The proteins are involved in global control of microtubule dynamics. They also localise to mitotic and meiotic spindles, where they contribute to formation and maintenance of spindle bipolarity, chromosomal congression, attachment correction and chromatid separation. In interphase cells, intricate and subtle mechanisms appear to allow kinesin-13 motors to act on specific populations of microtubules. Such carefully controlled localisation and regulation makes these kinesins efficient, multi-tasking molecular motors.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Kinesin-13, Microtubule, Depolymerisation, MCAK, Cell division
    School: School of Science > Biological Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Carolyn Moores
    Date Deposited: 23 Jun 2016 13:26
    Last Modified: 09 Feb 2021 21:58
    URI: https://eprints.bbk.ac.uk/id/eprint/15609

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