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    Structural biology of bacterial Type IV secretion systems

    Chandran Darbari, V. and Waksman, Gabriel (2015) Structural biology of bacterial Type IV secretion systems. Annual Review of Biochemistry 84 (1), pp. 603-629. ISSN 0066-4154.

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    Type IV secretion systems (T4SSs) are large multisubunit translocons, found in both gram-negative and gram-positive bacteria and in some archaea. These systems transport a diverse array of substrates from DNA and protein–DNA complexes to proteins, and play fundamental roles in both bacterial pathogenesis and bacterial adaptation to the cellular milieu in which bacteria live. This review describes the various biochemical and structural advances made toward understanding the biogenesis, architecture, and function of T4SSs.


    Item Type: Article
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 05 Jul 2016 10:24
    Last Modified: 02 Aug 2023 17:25


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