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    Beyond the known functions of the CCR4-NOT complex in gene expression regulatory mechanisms

    Ukleja, Marta and Valpuesta, J.M. and Dziembowski, A. and Cuellar, J. (2016) Beyond the known functions of the CCR4-NOT complex in gene expression regulatory mechanisms. BioEssays 38 (10), pp. 1048-1058. ISSN 0265-9247.

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    Large protein assemblies are usually the effectors of major cellular processes. The intricate cell homeostasis network is divided into numerous interconnected pathways, each controlled by a set of protein machines. One of these master regulators is the CCR4-NOT complex, which ultimately controls protein expression levels. This multisubunit complex assembles around a scaffold platform, which enables a wide variety of well-studied functions from mRNA synthesis to transcript decay, as well as other tasks still being identified. Solving the structure of the entire CCR4-NOT complex will help to define the distribution of its functions. The recently published three-dimensional reconstruction of the complex, in combination with the known crystal structures of some of the components, has begun to address this. Methodological improvements in structural biology, especially in cryoelectron microscopy, encourage further structural and protein-protein interaction studies, which will advance our comprehension of the gene expression machinery.


    Item Type: Article
    Keyword(s) / Subject(s): CCR4-NOT, protein degradation, protein expression, structural biology
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 10 Nov 2016 10:26
    Last Modified: 02 Aug 2023 17:26


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