Voltage-gated sodium channels as targets for pyrethroid insecticides

Field, L.M. and Emyr Davies, T.G. and O’Reilly, A.O. and Williamson, M.S. and Wallace, Bonnie A. (2017) Voltage-gated sodium channels as targets for pyrethroid insecticides. European Biophysics Journal with Biophysics letters 46 (7), pp. 675-679. ISSN 0175-7571.

Abstract

The pyrethroid insecticides are a very successful group of compounds that have been used extensively for the control of arthropod pests of agricultural crops and vectors of animal and human disease. Unfortunately, this has led to the development of resistance to the compounds in many species. The mode of action of pyrethroids is known to be via interactions with the voltage-gated sodium channel. Understanding how binding to the channel is affected by amino acid substitutions that give rise to resistance has helped to elucidate the mode of action of the compounds and the molecular basis of their selectivity for insects vs mammals and between insects and other arthropods. Modelling of the channel/pyrethroid interactions, coupled with the ability to express mutant channels in oocytes and study function, has led to knowledge of both how the channels function and potentially how to design novel insecticides with greater species selectivity.

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