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    Non-invasive measurement of a metabolic marker of infant brain function

    Siddiqui, M.F. and Lloyd-Fox, Sarah and Kaynezhad, P. and Tachtsidis, I. and Johnson, Mark H. and Elwell, C.E. (2017) Non-invasive measurement of a metabolic marker of infant brain function. Scientific Reports 7 (1), ISSN 2045-2322.

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    While near-infrared spectroscopy (NIRS) haemodynamic measures have proven to be vastly useful in investigating human brain development, the haemodynamic response function (HRF) in infants is not yet fully understood. NIRS measurements of the oxidation state of mitochondrial enzyme cytochrome-c-oxidase (oxCCO) have the potential to yield key information about cellular oxygen utilisation and therefore energy metabolism. We used a broadband NIRS system to measure changes in oxCCO, in addition to haemodynamic changes, during functional activation in a group of 33 typically developing infants aged between 4 and 6 months. The responses were recorded over the right temporal lobe while the infants were presented with engaging videos containing social content. A significant increase in oxCCO was found in response to the social stimuli, with maximum increase of 0.238 ± 0.13 μM. These results are the first reported significant change in oxCCO in response to stimulus-evoked activation in human infants and open new vistas for investigating human infant brain function and its energy metabolism.


    Item Type: Article
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Psychological Sciences
    Depositing User: Administrator
    Date Deposited: 18 Jul 2017 15:53
    Last Modified: 02 Aug 2023 17:33


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