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    Structural and molecular biology of a protein-polymerizing nanomachine for pilus biogenesis

    Waksman, Gabriel (2017) Structural and molecular biology of a protein-polymerizing nanomachine for pilus biogenesis. Journal of Molecular Biology 429 (17), pp. 2654-2666. ISSN 0022-2836.

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    Abstract

    Bacteria produce protein polymers on their surface called pili or fimbriae that serve either as attachment devices or as conduits for secreted substrates. This review will focus on the chaperone–usher pathway of pilus biogenesis, a widespread assembly line for pilus production at the surface of Gram-negative bacteria and the archetypical protein-polymerizing nanomachine. Comparison with other nanomachines polymerizing other types of biological units, such as nucleotides during DNA replication, provides some unifying principles as to how multidomain proteins assemble biological polymers.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Pilus biogenesis, Usher, Chaperone, DNA polymerase I, Nanomachine
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Depositing User: Administrator
    Date Deposited: 21 Jul 2017 12:34
    Last Modified: 02 Aug 2023 17:34
    URI: https://eprints.bbk.ac.uk/id/eprint/19232

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